Publications

Selected publications

Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications. Van Herck Y, Antoranz A, Andhari MD, Milli G, Bechter O, De Smet F, Bosisio FM.Front Oncol. 2021 Mar 29;11:636681. doi: 10.3389/fonc.2021.636681. eCollection 2021.PMID: 33854972

High dimensional profiling identifies specific immune types along the recovery trajectories of critically ill COVID19 patients. Penttilä PA, Van Gassen S, Panovska D, Vanderbeke L, Van Herck Y, Quintelier K, Emmaneel A, Filtjens J, Malengier-Devlies B, Ahmadzadeh K, Van Mol P, Borràs DM, Antoranz A, Bosisio FM, Wauters E, Martinod K, Matthys P, Saeys Y, Garg AD, Wauters J, De Smet F; CONTAGIOUS consortium.Cell Mol Life Sci. 2021 Mar 13:1-16. doi: 10.1007/s00018-021-03808-8. Online ahead of print.PMID: 33715015

Immunocompetent Mouse Models in the Search for Effective Immunotherapy in Glioblastoma. Wouters R, Bevers S, Riva M, De Smet F, Coosemans A.Cancers (Basel). 2020 Dec 23;13(1):19. doi: 10.3390/cancers13010019.PMID: 33374542

Next-Generation Pathology by Multiplexed Immunohistochemistry. De Smet F, Antoranz Martinez A, Bosisio FM.Trends Biochem Sci. 2021 Jan;46(1):80-82. doi: 10.1016/j.tibs.2020.09.009. Epub 2020 Oct 20.PMID: 33097382

All publications

2021

Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications. Van Herck Y, Antoranz A, Andhari MD, Milli G, Bechter O, De Smet F, Bosisio FM.Front Oncol. 2021 Mar 29;11:636681. doi: 10.3389/fonc.2021.636681. eCollection 2021.PMID: 33854972

A Multi-Omics Analysis of Metastatic Melanoma Identifies a Germinal Center-Like Tumor Microenvironment in HLA-DR-Positive Tumor Areas. Gadeyne L, Van Herck Y, Milli G, Atak ZK, Bolognesi MM, Wouters J, Marcelis L, Minia A, Pliaka V, Roznac J, Alexopoulos LG, Cattoretti G, Bechter O, Oord JVD, De Smet F, Antoranz A, Bosisio FM.Front Oncol. 2021 Mar 25;11:636057. doi: 10.3389/fonc.2021.636057. eCollection 2021.PMID: 33842341

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Pombo Antunes AR, Scheyltjens I, Lodi F, Messiaen J, Antoranz A, Duerinck J, Kancheva D, Martens L, De Vlaminck K, Van Hove H, Kjølner Hansen SS, Bosisio FM, Van der Borght K, De Vleeschouwer S, Sciot R, Bouwens L, Verfaillie M, Vandamme N, Vandenbroucke RE, De Wever O, Saeys Y, Guilliams M, Gysemans C, Neyns B, De Smet F, Lambrechts D, Van Ginderachter JA, Movahedi K.Nat Neurosci. 2021 Apr;24(4):595-610. doi: 10.1038/s41593-020-00789-y. Epub 2021 Mar 29.PMID: 33782623

High dimensional profiling identifies specific immune types along the recovery trajectories of critically ill COVID19 patients. Penttilä PA, Van Gassen S, Panovska D, Vanderbeke L, Van Herck Y, Quintelier K, Emmaneel A, Filtjens J, Malengier-Devlies B, Ahmadzadeh K, Van Mol P, Borràs DM, Antoranz A, Bosisio FM, Wauters E, Martinod K, Matthys P, Saeys Y, Garg AD, Wauters J, De Smet F; CONTAGIOUS consortium.Cell Mol Life Sci. 2021 Mar 13:1-16. doi: 10.1007/s00018-021-03808-8. Online ahead of print.PMID: 33715015

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages. Wauters E, Van Mol P, Garg AD, Jansen S, Van Herck Y, Vanderbeke L, Bassez A, Boeckx B, Malengier-Devlies B, Timmerman A, Van Brussel T, Van Buyten T, Schepers R, Heylen E, Dauwe D, Dooms C, Gunst J, Hermans G, Meersseman P, Testelmans D, Yserbyt J, Tejpar S, De Wever W, Matthys P; CONTAGIOUS collaborators, Neyts J, Wauters J, Qian J, Lambrechts D.Cell Rs. 2021 Mar;31(3):272-290. doi: 10.1038/s41422-020-00455-9. Epub 2021 Jan 21.PMID: 33473155

2020

Immunocompetent Mouse Models in the Search for Effective Immunotherapy in Glioblastoma. Wouters R, Bevers S, Riva M, De Smet F, Coosemans A.Cancers (Basel). 2020 Dec 23;13(1):19. doi: 10.3390/cancers13010019.PMID: 33374542

Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19. Neumann J, Prezzemolo T, Vanderbeke L, Roca CP, Gerbaux M, Janssens S, Willemsen M, Burton O, Van Mol P, Van Herck Y; CONTAGIOUS co‐authors, Wauters J, Wauters E, Liston A, Humblet-Baron S.Clin Transl Immunology. 2020 Nov 13;9(11):e1204. doi: 10.1002/cti2.1204. eCollection 2020.PMID: 33209300

Next-Generation Pathology by Multiplexed Immunohistochemistry. De Smet F, Antoranz Martinez A, Bosisio FM.Trends Biochem Sci. 2021 Jan;46(1):80-82. doi: 10.1016/j.tibs.2020.09.009. Epub 2020 Oct 20.PMID: 33097382

Establishing a Unified COVID-19 "Immunome": Integrating Coronavirus Pathogenesis and Host Immunopathology. Wauters E, Thevissen K, Wouters C, Bosisio FM, De Smet F, Gunst J, Humblet-Baron S, Lambrechts D, Liston A, Matthys P, Neyts J, Proost P, Weynand B, Wauters J, Tejpar S, Garg AD.Front Immunol. 2020 Jul 3;11:1642. doi: 10.3389/fimmu.2020.01642. eCollection 2020.PMID: 32719686

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis. Rohlenova K, Goveia J, García-Caballero M, Subramanian A, Kalucka J, Treps L, Falkenberg KD, de Rooij LPMH, Zheng Y, Lin L, Sokol L, Teuwen LA, Geldhof V, Taverna F, Pircher A, Conradi LC, Khan S, Stegen S, Panovska D, De Smet F, Staal FJT, Mclaughlin RJ, Vinckier S, Van Bergen T, Ectors N, De Haes P, Wang J, Bolund L, Schoonjans L, Karakach TK, Yang H, Carmeliet G, Liu Y, Thienpont B, Dewerchin M, Eelen G, Li X, Luo Y, Carmeliet P.Cell Metab. 2020 Apr 7;31(4):862-877.e14. doi: 10.1016/j.cmet.2020.03.009.PMID: 32268117

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates. Goveia J, Rohlenova K, Taverna F, Treps L, Conradi LC, Pircher A, Geldhof V, de Rooij LPMH, Kalucka J, Sokol L, García-Caballero M, Zheng Y, Qian J, Teuwen LA, Khan S, Boeckx B, Wauters E, Decaluwé H, De Leyn P, Vansteenkiste J, Weynand B, Sagaert X, Verbeken E, Wolthuis A, Topal B, Everaerts W, Bohnenberger H, Emmert A, Panovska D, De Smet F, Staal FJT, Mclaughlin RJ, Impens F, Lagani V, Vinckier S, Mazzone M, Schoonjans L, Dewerchin M, Eelen G, Karakach TK, Yang H, Wang J, Bolund L, Lin L, Thienpont B, Li X, Lambrechts D, Luo Y, Carmeliet P.Cancer Cell. 2020 Mar 16;37(3):421. doi: 10.1016/j.ccell.2020.03.002.PMID: 32183954

2018

Linking single-cell measurements of mass, growth rate, and gene expression. Kimmerling RJ, Prakadan SM, Gupta AJ, Calistri NL, Stevens MM, Olcum S, Cermak N, Drake RS, Pelton K, De Smet F, Ligon KL, Shalek AK, Manalis SR.Genome Biol. 2018 Nov 27;19(1):207. doi: 10.1186/s13059-018-1576-0.PMID: 30482222

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